UMass Chan Medical SchoolMorningside Graduate School of Biomedical SciencesDepartment of Microbiology
Irazoqui Lab

Publications

Papers from the lab

A complete list, newest first, with free full text where available. Lab members from our publication record appear in the People page.

My NCBI bibliography Google Scholar

Highlights

Selected papers

Immunity 2014

TFEB drives host defense

HLH-30/TFEB switches on most of the worm's response to S. aureus.

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Cell Reports 2016

A pathway kept for a billion years

A PLC-PKD-TFEB chain works in worms and in mouse macrophages.

Read

Immunity 2018

Nerves arm the gut

Acetylcholine from neurons triggers Wnt-driven defense in the gut lining.

Read

eLife 2021

Two regulators, one defense gene

NHR-49 and HLH-30 cooperate through the monooxygenase FMO-2.

Read

Autophagy 2022

How macrophages flip TFEB on

Reactive oxygen acts through CD38 and NAADP during phagocytosis.

Read

Trends in Immunology 2020

MiT factors in immunity

A review of TFEB and TFE3 in innate immunity and inflammation.

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Complete list

All publications

From PubMed. Lab head in bold. Preprints later published as peer-reviewed papers are listed once, under the published version.

  1. 2026

    Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans.Collaboration

    Valenzuela-Villatoro M, de la Cruz-Ruiz P, Guerrero-Gómez D, Gómez-Orte E, Schiavi A, Maglioni S, et al. (with Irazoqui JE) Redox Biol. 2026;93:104115. PMID 41996933; PMCID PMC13099523.

    PubMed record for PMID 41996933Free full text (PMC) for PMID 41996933Journal page for PMID 41996933

  2. 2025

    Staphylococcus aureus-induced degeneration of nociceptive neurons in Caenorhabditis elegans.

    DiLoreto EM, Gonzalez X, Wani KA, Shen J, Irazoqui JE, Srinivasan J. BMC Biol. 2025;24(1):2. PMID 41327171; PMCID PMC12777361.

    PubMed record for PMID 41327171Free full text (PMC) for PMID 41327171Journal page for PMID 41327171

  3. 2025

    LIPL-1 and LIPL-2 are TCER-1-regulated lysosomal lipases with distinct roles in immunity and fertility.Preprint

    Bahr L, Amrit FR, Silvia PE, Bui D, Wayhs B, Choe M, et al. (with Irazoqui JE) bioRxiv. 2025. PMID 40791391; PMCID PMC12338661.

    PubMed record for PMID 40791391Free full text (PMC) for PMID 40791391Journal page for PMID 40791391

  4. 2025

    TFEB-mediated proinflammatory response in murine macrophages induced by acute Alpha7 nicotinic receptor activation.

    Honwad HH, Najibi M, Shen J, Watts S, Fu AM, Koscso B, Bogunovic M, Irazoqui JE. J Leukoc Biol. 2025;117(6):qiaf077. PMID 40435320; PMCID PMC12202934.

    PubMed record for PMID 40435320Free full text (PMC) for PMID 40435320Journal page for PMID 40435320

  5. 2025

    Systems neuroimmunology: current bottlenecks, research priorities and future directions.Perspective

    Iyer H, Benoist C, Bilbo SD, Boulanger LM, Burton MD, Daniels BP, et al. (with Irazoqui JE) Nat Immunol. 2025;26(3):325-329. PMID 39939753; PMCID PMC12016954.

    PubMed record for PMID 39939753Free full text (PMC) for PMID 39939753Journal page for PMID 39939753

  6. 2024

    Regulation of Caenorhabditis elegans HLH-30 subcellular localization dynamics: evidence for a redox-dependent mechanism.Collaboration

    Colino-Lage H, Guerrero-Gómez D, Gómez-Orte E, González X, Martina JA, Dansen TB, et al. (with Irazoqui JE) Free Radic Biol Med. 2024;223:369-383. PMID 39059513; PMCID PMC11977398.

    PubMed record for PMID 39059513Free full text (PMC) for PMID 39059513Journal page for PMID 39059513

  7. 2024

    Glucose-fed microbiota alters C. elegans intestinal epithelium and increases susceptibility to multiple bacterial pathogens.Collaboration

    Kingsley SF, Seo Y, Wood A, Wani KA, Gonzalez X, Irazoqui J, Finkel SE, Tissenbaum HA. Sci Rep. 2024;14(1):13177. PMID 38849503; PMCID PMC11161463.

    PubMed record for PMID 38849503Free full text (PMC) for PMID 38849503Journal page for PMID 38849503

  8. 2024

    Distinct members of the Caenorhabditis elegans CeMbio reference microbiota exert cryptic virulence that is masked by host defense.

    Gonzalez X, Irazoqui JE. Mol Microbiol. 2024;122(3):387-402. PMID 38623070; PMCID PMC11480257.

    PubMed record for PMID 38623070Free full text (PMC) for PMID 38623070Journal page for PMID 38623070

  9. 2023

    C. elegans orphan nuclear receptor NHR-42 represses innate immunity and promotes lipid loss downstream of HLH-30/TFEB.

    Goswamy D, Gonzalez X, Labed SA, Irazoqui JE. Front Immunol. 2023;14:1094145. PMID 36860863; PMCID PMC9968933.

    PubMed record for PMID 36860863Free full text (PMC) for PMID 36860863Journal page for PMID 36860863

  10. 2022

    A novel NOX/PHOX-CD38-NAADP-TFEB axis important for macrophage activation during bacterial phagocytosis.

    Najibi M, Honwad HH, Moreau JA, Becker SM, Irazoqui JE. Autophagy. 2022;18(1):124-141. PMID 33818279; PMCID PMC8865266.

    PubMed record for PMID 33818279Free full text (PMC) for PMID 33818279Journal page for PMID 33818279

  11. 2022

    Editorial: C. elegans host-microbiome interactions: from medical to ecological and evolutionary model.Editorial

    Herman MA, Irazoqui JE, Samuel BS, Vega N. Front Cell Infect Microbiol. 2022;12:1035545. PMID 36225234; PMCID PMC9549332.

    PubMed record for PMID 36225234Free full text (PMC) for PMID 36225234Journal page for PMID 36225234

  12. 2021

    NHR-49/PPAR-α and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase.

    Wani KA, Goswamy D, Taubert S, Ratnappan R, Ghazi A, Irazoqui JE. eLife. 2021;10:e62775. PMID 33978570; PMCID PMC8139828.

    PubMed record for PMID 33978570Free full text (PMC) for PMID 33978570Journal page for PMID 33978570

  13. 2021

    A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans.Review

    Goswamy D, Irazoqui JE. Curr Opin Immunol. 2021;68:9-20. Corrigendum: PMID 40603234. PMID 32898751; PMCID PMC7925333.

    PubMed record for PMID 32898751Free full text (PMC) for PMID 32898751Journal page for PMID 32898751

  14. 2021

    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).Guidelines

    Klionsky DJ, et al. (consortium including Irazoqui JE) Autophagy. 2021;17(1):1-382. PMID 33634751; PMCID PMC7996087.

    PubMed record for PMID 33634751Free full text (PMC) for PMID 33634751Journal page for PMID 33634751

  15. 2020

    Key roles of MiT transcription factors in innate immunity and inflammation.Review

    Irazoqui JE. Trends Immunol. 2020;41(2):157-171. PMID 31959514; PMCID PMC6995440.

    PubMed record for PMID 31959514Free full text (PMC) for PMID 31959514Journal page for PMID 31959514

  16. 2020

    Nervous system control of intestinal host defense in C. elegans.Review

    Wani KA, Goswamy D, Irazoqui JE. Curr Opin Neurobiol. 2020;62:1-9. PMID 31790812; PMCID PMC7255937.

    PubMed record for PMID 31790812Free full text (PMC) for PMID 31790812Journal page for PMID 31790812

  17. 2019

    A nutrition-longevity tradeoff enforced by innate immunity.Commentary

    Wani KA, Goswamy D, Irazoqui JE. Mol Cell. 2019;74(5):864-865. PMID 31173721.

    PubMed record for PMID 31173721Journal page for PMID 31173721

  18. 2018

    Intestinal epithelial Wnt signaling mediates acetylcholine-triggered host defense against infection.

    Labed SA, Wani KA, Jagadeesan S, Hakkim A, Najibi M, Irazoqui JE. Immunity. 2018;48(5):963-978.e3. PMID 29768179; PMCID PMC5959051.

    PubMed record for PMID 29768179Free full text (PMC) for PMID 29768179Journal page for PMID 29768179

  19. 2017

    Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo.

    Murano T, Najibi M, Paulus GLC, Adiliaghdam F, Valencia-Guerrero A, Selig M, et al. (with Irazoqui JE, senior author) Sci Rep. 2017;7(1):13938. PMID 29066772; PMCID PMC5655326.

    PubMed record for PMID 29066772Free full text (PMC) for PMID 29066772Journal page for PMID 29066772

  20. 2016

    An evolutionarily conserved PLC-PKD-TFEB pathway for host defense.

    Najibi M, Labed SA, Visvikis O, Irazoqui JE. Cell Rep. 2016;15(8):1728-42. PMID 27184844; PMCID PMC4880541.

    PubMed record for PMID 27184844Free full text (PMC) for PMID 27184844Journal page for PMID 27184844

  21. 2016

    FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth hormone.Collaboration

    Srinivasa S, Suresh C, Mottla J, Hamarneh SR, Irazoqui JE, Frontera W, et al. Growth Horm IGF Res. 2016;26:36-41. PMID 26774404; PMCID PMC4716612.

    PubMed record for PMID 26774404Free full text (PMC) for PMID 26774404Journal page for PMID 26774404

  22. 2016

    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Guidelines

    Klionsky DJ, et al. (consortium including Irazoqui JE) Autophagy. 2016;12(1):1-222. PMID 26799652; PMCID PMC4835977.

    PubMed record for PMID 26799652Free full text (PMC) for PMID 26799652Journal page for PMID 26799652

  23. 2015

    Why worms watch their hemidesmosomes and why you should, too.Commentary

    Irazoqui JE. Immunity. 2015;42(2):206-208. PMID 25692695.

    PubMed record for PMID 25692695Journal page for PMID 25692695

  24. 2015

    Relationship between serum IGF-1 and skeletal muscle IGF-1 mRNA expression to phosphocreatine recovery after exercise in obese men with reduced GH.Collaboration

    Hamarneh SR, Murphy CA, Shih CW, Frontera W, Torriani M, Irazoqui JE, Makimura H. J Clin Endocrinol Metab. 2015;100(2):617-25. PMID 25375982; PMCID PMC4318910.

    PubMed record for PMID 25375982Free full text (PMC) for PMID 25375982Journal page for PMID 25375982

  25. 2014

    Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.

    Visvikis O, Ihuegbu N, Labed SA, Luhachack LG, Alves AF, Wollenberg AC, Stuart LM, Stormo GD, Irazoqui JE. Immunity. 2014;40(6):896-909. PMID 24882217; PMCID PMC4104614.

    PubMed record for PMID 24882217Free full text (PMC) for PMID 24882217Journal page for PMID 24882217

  26. 2014

    DAF-tly depart stinky situations with elegans.Commentary

    Irazoqui JE. Cell Host Microbe. 2014;16(5):553-5. PMID 25525785.

    PubMed record for PMID 25525785Journal page for PMID 25525785

  27. 2013

    The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.Collaboration

    Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, et al. (with Irazoqui JE) Nat Commun. 2013;4:2267. PMID 23925298; PMCID PMC3866206.

    PubMed record for PMID 23925298Free full text (PMC) for PMID 23925298Journal page for PMID 23925298

  28. 2013

    TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop.Collaboration

    Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, Visvikis O, et al. (with Irazoqui JE) Nat Cell Biol. 2013;15(6):647-58. PMID 23604321; PMCID PMC3699877.

    PubMed record for PMID 23604321Free full text (PMC) for PMID 23604321Journal page for PMID 23604321

  29. 2012

    Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids.Collaboration

    Brown S, Xia G, Luhachack LG, Campbell J, Meredith TC, Chen C, et al. (with Irazoqui JE) Proc Natl Acad Sci U S A. 2012;109(46):18909-14. PMID 23027967; PMCID PMC3503181.

    PubMed record for PMID 23027967Free full text (PMC) for PMID 23027967Journal page for PMID 23027967

  30. 2012

    An image analysis toolbox for high-throughput C. elegans assays.Collaboration

    Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, et al. (with Irazoqui JE) Nat Methods. 2012;9(7):714-6. PMID 22522656; PMCID PMC3433711.

    PubMed record for PMID 22522656Free full text (PMC) for PMID 22522656Journal page for PMID 22522656

  31. 2012

    EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.

    Luhachack LG, Visvikis O, Wollenberg AC, Lacy-Hulbert A, Stuart LM, Irazoqui JE. PLoS Pathog. 2012;8(7):e1002798. PMID 22792069; PMCID PMC3390412.

    PubMed record for PMID 22792069Free full text (PMC) for PMID 22792069Journal page for PMID 22792069

Earlier papers, 1999 to 2011: training at Duke University and Massachusetts General Hospital
  1. 2011

    Transparent worms help survey the fortress of innate immunity.Commentary

    Irazoqui JE. Virulence. 2011;2(2):83-5. PMID 21460640.

    PubMed record for PMID 21460640Journal page for PMID 21460640

  2. 2010

    Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus.

    Irazoqui JE, Troemel ER, Feinbaum RL, Luhachack LG, Cezairliyan BO, Ausubel FM. PLoS Pathog. 2010;6(7):e1000982. PMID 20617181; PMCID PMC2895663.

    PubMed record for PMID 20617181Free full text (PMC) for PMID 20617181Journal page for PMID 20617181

  3. 2010

    99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Caenorhabditis elegans as a model to study tissues involved in host immunity and microbial pathogenesis.Review

    Irazoqui JE, Ausubel FM. Clin Exp Immunol. 2010;160(1):48-57. PMID 20415851; PMCID PMC2841835.

    PubMed record for PMID 20415851Free full text (PMC) for PMID 20415851Journal page for PMID 20415851

  4. 2010

    Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates.Review

    Irazoqui JE, Urbach JM, Ausubel FM. Nat Rev Immunol. 2010;10(1):47-58. PMID 20029447; PMCID PMC2965059.

    PubMed record for PMID 20029447Free full text (PMC) for PMID 20029447Journal page for PMID 20029447

  5. 2008

    Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.

    Irazoqui JE, Ng A, Xavier RJ, Ausubel FM. Proc Natl Acad Sci U S A. 2008;105(45):17469-74. PMID 18981407; PMCID PMC2582251.

    PubMed record for PMID 18981407Free full text (PMC) for PMID 18981407Journal page for PMID 18981407

  6. 2005

    Opposing roles for actin in Cdc42p polarization.

    Irazoqui JE, Howell AS, Theesfeld CL, Lew DJ. Mol Biol Cell. 2005;16(3):1296-304. PMID 15616194; PMCID PMC551493.

    PubMed record for PMID 15616194Free full text (PMC) for PMID 15616194Journal page for PMID 15616194

  7. 2004

    Cdc42p, GTP hydrolysis, and the cell's sense of direction.Review

    Irazoqui JE, Gladfelter AS, Lew DJ. Cell Cycle. 2004;3(7):861-4. PMID 15190213.

    PubMed record for PMID 15190213

  8. 2004

    Polarity establishment in yeast.

    Irazoqui JE, Lew DJ. J Cell Sci. 2004;117(Pt 11):2169-71. PMID 15126618.

    PubMed record for PMID 15126618Journal page for PMID 15126618

  9. 2003

    Scaffold-mediated symmetry breaking by Cdc42p.

    Irazoqui JE, Gladfelter AS, Lew DJ. Nat Cell Biol. 2003;5(12):1062-70. PMID 14625559.

    PubMed record for PMID 14625559Journal page for PMID 14625559

  10. 2001

    Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.

    Bose I, Irazoqui JE, Moskow JJ, Bardes ES, Zyla TR, Lew DJ. J Biol Chem. 2001;276(10):7176-86. PMID 11113154.

    PubMed record for PMID 11113154Journal page for PMID 11113154

  11. 1999

    The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle.

    Theesfeld CL, Irazoqui JE, Bloom K, Lew DJ. J Cell Biol. 1999;146(5):1019-32. PMID 10477756; PMCID PMC2169477.

    PubMed record for PMID 10477756Free full text (PMC) for PMID 10477756Journal page for PMID 10477756